Depression Treatment in Palm Beach, FL

Depression is not a character flaw, a sign of weakness, or something you can simply will yourself out of. It is a serious medical condition that affects the brain, body, and behavior. At his Palm Beach psychiatric practice, Dr. Mark G. Agresti, M.D. offers comprehensive, evidence-based depression treatment that goes well beyond standard antidepressant prescriptions.

Types of Depressive Disorders Dr. Agresti Treats

Depression is not a single diagnosis but a spectrum of conditions. Dr. Agresti evaluates and manages:

• Major Depressive Disorder (MDD) — persistent depressed mood or loss of interest lasting two or more weeks, significantly impairing daily function
• Persistent Depressive Disorder (Dysthymia) — chronic low-grade depression lasting two or more years
• Treatment-Resistant Depression (TRD) — depression that has not responded adequately to two or more antidepressant trials
• Seasonal Affective Disorder (SAD) — depressive episodes tied to seasonal changes in light exposure
• Postpartum Depression — depression emerging after childbirth, requiring specialized assessment and care
• Depression with anxious distress or psychotic features — more complex presentations requiring tailored pharmacology

Recognizing the Symptoms of Depression

Depression affects mood, thinking, physical health, and behavior. Symptoms commonly include:

• Persistent sadness, emptiness, or hopelessness most of the day, nearly every day
• Loss of interest or pleasure in activities that were once enjoyable
• Significant changes in appetite and weight
• Sleep disturbances — insomnia or sleeping too much
• Fatigue and loss of energy
• Difficulty concentrating, remembering, or making decisions
• Feelings of worthlessness or excessive, inappropriate guilt
• Slowed movement or speech, or restlessness and agitation
• Thoughts of death or suicide

If you are experiencing thoughts of suicide or self-harm, please call 988 (Suicide and Crisis Lifeline) or go to your nearest emergency room. For ongoing psychiatric care, Dr. Agresti’s office can be reached at 561-760-4107.

Dr. Agresti’s Approach to Depression Treatment

Dr. Agresti begins with a comprehensive psychiatric evaluation to understand the full scope of your depression: when it started, what triggers it, how it has responded to prior treatments, and how it intersects with your overall health and life circumstances. This thoroughness is especially important because depression frequently co-occurs with anxiety, substance use, chronic pain, and other medical conditions.

Expert Medication Management

Antidepressant selection is not one-size-fits-all. Dr. Agresti specializes in complex psychopharmacology, with particular expertise in patients who have tried multiple medications without success. He considers medication history, side-effect profiles, genetic factors, and the specific subtype and severity of depression when crafting a treatment plan.

Medication categories used in depression treatment may include:

• SSRIs (sertraline, fluoxetine, escitalopram) and SNRIs (venlafaxine, duloxetine) — foundational first-line agents
• Atypical antidepressants (bupropion, mirtazapine) — useful when SSRIs are ineffective or cause intolerable side effects
• Mood stabilizers and atypical antipsychotics — augmentation strategies for partial responders or complex presentations
• TCAs and MAOIs — considered when modern agents have failed, with appropriate monitoring

Ketamine and Spravato for Treatment-Resistant Depression

For patients who have tried multiple antidepressants without adequate relief, Dr. Agresti offers ketamine infusion therapy and Spravato (esketamine) — FDA-approved options that can produce rapid antidepressant effects, sometimes within hours to days. These treatments represent a major advance for patients with treatment-resistant depression and those with active suicidal ideation who need fast-acting intervention.

Telehealth Depression Treatment Across Florida

Dr. Agresti provides telehealth psychiatric care for depression patients throughout Florida. Telehealth is particularly valuable for people whose depression makes leaving home difficult, those with mobility limitations, or patients who live far from Palm Beach. Secure video appointments are available for new and established patients.

Why Choose Dr. Mark Agresti for Depression Treatment

• Nationally recognized expertise in treatment-resistant depression — including ketamine and Spravato
• Complex psychopharmacology specialist — the right choice when simpler approaches have failed
• Comprehensive evaluation — every patient receives a thorough, individualized assessment
• Compassionate, unhurried care in a discreet, professional Palm Beach setting
• Telehealth available statewide for ongoing medication management and follow-up

Take the First Step Toward Recovery

Depression is treatable. With the right care, most patients achieve significant improvement in mood, energy, and quality of life. Dr. Agresti and his team are committed to finding the approach that works for you.

Dr. Mark G. Agresti, M.D.
44 Cocoanut Row, Suite m-202
Palm Beach, FL 33480

Call to schedule: 561-760-4107
Psychiatric emergencies: 561-386-7743

Telehealth appointments available for patients throughout Florida.