Sublocade
Monthly injectable buprenorphine — no daily pills, consistent levels, no diversion
Overview
Sublocade is a once-monthly subcutaneous injection of extended-release buprenorphine. After injection, a small depot forms under the skin that releases buprenorphine steadily over 30 days, maintaining consistent blood levels without daily dosing. This eliminates adherence issues, diversion risk, and the daily ritual of sublingual film — making it an excellent option for appropriate patients.
How It Works
Sublocade contains the same active ingredient as Suboxone (buprenorphine) but in a polymer matrix that releases the drug slowly over 30 days after subcutaneous injection. Blood levels are remarkably stable — no peaks, no troughs, no missed doses. Patients must be stable on sublingual buprenorphine for at least 7 days before initiating Sublocade.
Induction & Dosing
- Must be stabilized on sublingual buprenorphine (Suboxone) for at least 7 days before injection
- Administered by a healthcare provider as a subcutaneous injection in the abdomen
- Available in two doses: 100mg and 300mg monthly
- Transition from 300mg loading to 100mg maintenance after initial months if appropriate
Available Formulations
- Sublocade 100mg/0.5ml monthly injection
- Sublocade 300mg/1.5ml monthly injection (often used for loading doses)
- Administered in-office by a healthcare provider — cannot be self-administered
MAT With Direct Physician Access
Recovery requires support between appointments. With Dr. Agresti's concierge model, you have his direct cell number — text him about cravings, side effects, or concerns without waiting weeks for the next scheduled appointment. This level of access is especially critical in early MAT when induction and dose adjustment require close monitoring.
Schedule a MAT ConsultationCommon Questions
Who is Sublocade best for?
Sublocade is ideal for patients who: have diversion concerns, have adherence difficulties with daily sublingual film, want to eliminate the daily reminder of taking medication, have certain occupational considerations (professional drug testing of blood, not urine), or simply prefer the convenience of a monthly injection.
Does Sublocade hurt?
The injection uses a small gauge needle and is generally well tolerated. A small, firm lump forms at the injection site — this is the biodegradable polymer depot and is completely normal. It dissolves over the month as the medication is released.
Can I switch from Suboxone to Sublocade?
Yes — the standard protocol is to stabilize on sublingual buprenorphine for at least 7 days, then transition to Sublocade injections. The sublingual medication is stopped when Sublocade is initiated.